This video highlights a custom pressure–volume control system developed by CellScale in collaboration with Prof. Mona Eskandari at the University of California, Riverside to study lung mechanics.
Diseases such as asthma, emphysema, and COVID-19 alter pulmonary volume, viscoelasticity, and airflow distribution. To accurately measure lung volume during inflation and deflation, lungs were placed in a sealed chamber where changes in displaced volume were used to quantify lung expansion while maintaining atmospheric pressure.
The system was designed at two vastly different scales to accommodate both mouse and pig lungs, addressing challenges related to volume range and high flow rates. This work demonstrates CellScale’s ability to design and build custom mechanical testing solutions tailored to complex biomedical research applications.
