Ultra Low Force Mechanical Testing
For Soft Materials

Ultra low force mechanical testing enables precise measurement of forces at the micro-Newton scale, allowing researchers to characterize ultra soft materials, hydrogels, microtissues, thin films, and delicate biomaterials that cannot be evaluated using conventional testing systems.

Up close view of the Eclipse force sensor with a green gel-like sample being compressed for ultra low force mechanical testing
A polymer sphere being compressed on the MicroTester G2 compression testing machine

What Ultra Low Force Mechanical Testing Measures

Ultra low force testing systems quantify mechanical behaviour in materials that deform under very small loads. This approach is commonly referred to as micro Newton mechanical testing, reflecting the force resolution required for ultra soft and micro-scale specimens.

Because many biological constructs generate or resist extremely small forces, ultra low force mechanical testing is essential for accurate and reproducible data.

These measurements are essential for understanding soft biomaterial mechanics at force scales relevant to cellular and microtissue function, as well as for materials that fail, tear, or experience unintended deformation under standard force levels.

A screenshot of the Data Analysis software with MicroTester compression data

Ultra Low Force Testing in Biomaterials Research

Research involving ultra soft biomaterials requires precise force control and sensitive load measurement. These capabilities are central to ultra soft material testing, where even minimal loading can alter structure or induce damage. Ultra low force mechanical testing enables:

Common Sample Types for Ultra Low Force Testing

How Ultra Low Force Testing Works

Ultra low force mechanical testing uses specialized sensors and actuators designed to deliver and detect extremely small forces.

Beams or optical sensors capture forces too small for traditional load cells.

Small clamps, micro hooks, or fiber grips apply tension without damaging ultra soft samples. This configuration supports low force tensile testing of fibers, gels, and micro-scale constructs without grip-induced artifacts.

Indenters or small platens compress microtissues or gels with precise displacement control.

Systems operate at fine displacement increments to capture subtle mechanical changes.

Ultra soft samples often require fluid and thermal stability to maintain physiological mechanical behaviour.

Recommended CellScale Instruments for Ultra Low Force Testing

Two CellScale systems are capable of ultra low force mechanical testing with micro-Newton sensitivity for characterizing deformation and mechanics in ultra soft biomaterials.

Featured Publications Using Ultra Low Force Testing

Novel Vascular-Adaptive Liquid Metal Microspheres Enable Visualized Arterial Embolization Therapy

Shen C, Chen J, et al.

Advanced Science

MicroTester

Compression TestingHydrated and Temperature Controlled TestingMicro-Mechanical TestingTensile TestingUltra Low Force Testing

Drug Screening & Drug Delivery MechanicsInjectable & Regenerative Biomaterials

2026

Co-delivery of Human Adipose-Derived Stromal Cells and Endothelial Colony-Forming Cells in Cell-Assembled Decellularized Adipose Tissue Scaffolds for Applications in Soft Tissue Regeneration

From SA, Walker JT, et al.

Acta Biomaterialia

UniVert

Compression TestingMicro-Mechanical TestingUltra Low Force Testing

Cell Laden HydrogelsECM & Decellularized Matrix MechanicsInjectable & Regenerative BiomaterialsScaffold Mechanical TestingSkin and Wound Healing BiomechanicsVascular Tissue Engineering & Mechanics

2026

Enabling dual excitation-contraction recording and disease modeling via hydrogel-free heart tissue

Li J, Liu Y, et al.

Cell Reports Physical Science

MicroTester

Compression TestingMicro-Mechanical TestingUltra Low Force Testing

Cardiac Tissue Engineering & MechanicsDrug Screening & Drug Delivery MechanicsOrgan-On-A-Chip Systems

2026

Ready to Perform Ultra Low Force Mechanical Testing?

CellScale instruments provide micro-Newton scale measurement capabilities for ultra soft biomaterials and small-scale engineered constructs.

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