Oral Galvanism Side Effects: Comparing Alloy Ions and Galvanic Current Effects on the Mucosa-like Model

Chepelova N, Antoshin A, et al.

Journal of Functional Biomaterials

Sechenov First Moscow State Medical University, RUDN University

RESEARCH SUMMARY

This study explored cytotoxic and mechanical effects of oral galvanism caused by dental alloys and galvanic currents on mucosa-like tissue models. Results showed direct current caused acute cytotoxicity, while NiCr-AgPd corrosion ions induced long-term collagen stiffening.

The CellScale MicroTester G2 quantified Young’s modulus of collagen-based mucosa-like models using spherical indentation to 200 µm depth. Models exposed to NiCr–AgPd showed increased stiffness (11–14 kPa), revealing ion-induced matrix cross-linking.

AUTHORS

Natalia Chepelova; Artem Antoshin; Sergei Voloshin; Anna Usanova; Yuri Efremov; Maria Makeeva; Stanislav Evlashin; Mikhail Stepanov; Anna Turkina; Peter Timashev.

PUBLICATION DETAILS

JOURNAL

Journal of Functional Biomaterials

YEAR

2023

INSTITUTIONS

Sechenov First Moscow State Medical University, RUDN University

COUNTRIES

Russia

INSTRUMENT USED

MicroTester

TESTING METHODS

Hydrated and Temperature Controlled TestingIndentation TestingMicro-Mechanical Testing

RESEARCH APPLICATIONS

Dental & Oral Tissue BiomechanicsECM & Decellularized Matrix MechanicsFibrosis & Tissue RemodelingOrgan-On-A-Chip Systems

Related Publications:

Instrument Used:

Year:

Testing Method:

Research Application:

Country:

3D fractal topography attenuates inflammation and confers resilience to glomerular podocytes

Wang Y, Dikyol C, et al.

Cell Biomaterials

MicroTester

Hydrated and Temperature Controlled TestingIndentation TestingMicro-Mechanical Testing

Fibrosis & Tissue RemodelingMechanotransductionOrganoid and Tissue Mimetic Systems

2026

Mechanically graded granular scaffolds for osteochondral tissue engineering

Mierswa SC, Wheeler EE, et al.

Biomaterials Advances

MicroTester

Compression TestingHydrated and Temperature Controlled TestingMicro-Mechanical Testing

Bone Tissue Engineering & MechanicsCartilage and Meniscus MechanicsScaffold Mechanical Testing

2026

Tailorable Hydrogel Fibers from High-Yield Recombinant Hagfish Intermediate Filament Proteins: A New Frontier in Biomimetic Materials

Bell BE, Wasserman O, et al.

ACS Omega

MicroTester

Flexural and Bending TestingHydrated and Temperature Controlled TestingMicro-Mechanical Testing

Hydrogel Mechanical TestingMembranes and Thin Films Mechanics

2026