Towards constructing a generalized structural 3D breathing human lung model based on experimental volumes, pressures, and strains

This study developed a structurally representative three-dimensional human lung model informed by continuous experimental pressure, volume, and strain data collected from cadaveric human lungs. Organ-level inflation experiments were combined with tissue-level mechanical characterization to calibrate an inverse finite-element framework capable of reproducing physiological pressure–volume behavior and heterogeneous regional strain patterns. The resulting model successfully captured nonlinear pulmonary mechanics and provides a validated foundation for studying lung function, disease progression, and ventilation strategies.