G-Protein-Coupled Receptors Mediate Modulations of Cell Viability and Drug Sensitivity by Aberrantly Expressed Recoverin 3 within A549 Cells

This study examined how aberrant expression of recoverin alters GPCR signaling, metabolism, and mechanical phenotype in A549 lung adenocarcinoma cells. Overexpression increased drug sensitivity, induced oxidative metabolism, and stiffened 3D spheroids through GPCR-related mechanisms.