Polyglyoxylamide Hydrogels for the Traceless Stimulus-Mediated Release of Covalently-Immobilized Drugs

This work introduces self-immolative polyglyoxylamide (PGA) hydrogels capable of traceless drug release via cleavage-triggered polymer backbone degradation. Through tunable crosslinking and pendant linker chemistry, the hydrogels allow covalent drug immobilization followed by triggered release under physiological stimuli. Mechanical and swelling tests demonstrated excellent structural integrity and reversible degradation behavior. The platform offers potential for smart drug delivery systems where payload release is mediated by chemical or enzymatic signals without residual linker fragments.