Modeling the Effects of Cyclical Masticatory Forces in a 3D Oral Mucosal Model In Vitro

Robins S, Salih V, et al.

Tissue Engineering Part C: Methods

University of Plymouth, Haleon PLC

RESEARCH SUMMARY

Developed a 3D oral mucosal model subjected to cyclical compression (0–10 N) to mimic masticatory forces. Found force-dependent epithelial thinning, cytokine increase (IL-6, IL-8), and protective effects from denture adhesive.

Used the MechanoCulture TX to apply controlled cyclical compressive forces (0–10 N, 1 Hz, 2 h) on 3D oral mucosal constructs to simulate masticatory pressure and assess tissue response.

AUTHORS

Samantha Robins, Vehid Salih, Alastair Lomax, Sian Crow, Zoe Brookes, Andrew Foey, Simon A. Whawell.

PUBLICATION DETAILS

JOURNAL

Tissue Engineering Part C: Methods

YEAR

2025

INSTITUTIONS

University of Plymouth, Haleon PLC

COUNTRIES

United Kingdom

INSTRUMENT USED

MechanoCulture TX

TESTING METHODS

Compression TestingFatigue TestingHydrated and Temperature Controlled Testing

RESEARCH APPLICATIONS

Dental & Oral Tissue BiomechanicsFibrosis & Tissue RemodelingMechanotransduction

Related Publications:

Instrument Used:

Year:

Testing Method:

Research Application:

Country:

Mechanoregulation of MSC spheroid immunomodulation

Thai VL, Mierswa S, et al.

APL Bioengineering

MechanoCulture TX

Compression TestingHydrated and Temperature Controlled TestingViscoelastic & Time-Dependent Testing

Cell Laden HydrogelsMechanotransductionMicrotissue and Spheroid MechanicsStem Cell Mechanobiology

2024

Effect of Uniaxial Compression Frequency on Osteogenic Cell Responses in Dynamic 3D Cultures

Kontogianni G, Loukelis K, et al.

Bioengineering

MechanoCulture TX

Compression TestingFatigue Testing

3D Bioprinting & Bioink Materials TestingBone Tissue Engineering & MechanicsMechanotransductionPolymers and Elastomers TestingScaffold Mechanical Testing

2023

A Novel Injectable Piezoelectric Hydrogel for Periodontal Disease Treatment

Roldan L, Montoya C, et al.

ACS Applied Materials & Interfaces

MechanoCulture TX

Compression TestingHydrated and Temperature Controlled Testing

Dental & Oral Tissue BiomechanicsHydrogel Mechanical TestingInjectable & Regenerative BiomaterialsMechanotransduction

2023