Modeling the Effects of Cyclical Masticatory Forces in a 3D Oral Mucosal Model In Vitro

Robins S, Salih V, et al.

Tissue Engineering Part C: Methods

University of Plymouth, Haleon PLC

RESEARCH SUMMARY

Developed a 3D oral mucosal model subjected to cyclical compression (0–10 N) to mimic masticatory forces. Found force-dependent epithelial thinning, cytokine increase (IL-6, IL-8), and protective effects from denture adhesive.

Used the MechanoCulture TX to apply controlled cyclical compressive forces (0–10 N, 1 Hz, 2 h) on 3D oral mucosal constructs to simulate masticatory pressure and assess tissue response.

AUTHORS

Samantha Robins, Vehid Salih, Alastair Lomax, Sian Crow, Zoe Brookes, Andrew Foey, Simon A. Whawell.

PUBLICATION DETAILS

JOURNAL

Tissue Engineering Part C: Methods

YEAR

2025

INSTITUTIONS

University of Plymouth, Haleon PLC

COUNTRIES

United Kingdom

INSTRUMENT USED

MechanoCulture TX

TESTING METHODS

Compression TestingFatigue TestingHydrated and Temperature Controlled Testing

RESEARCH APPLICATIONS

Dental & Oral Tissue BiomechanicsFibrosis & Tissue RemodelingMechanotransduction

Related Publications:

Instrument Used:

Year:

Testing Method:

Research Application:

Country:

Mechanical loading under estrogen deficiency enhances mineralization and osteoblast maturation in an advanced 3D vascularized bone organoid driven by hypertrophy and apoptosis

Bukhari MMM, Naqvi SM, et al.

Journal of Biomechanics

MechanoCulture TX

Compression TestingFatigue TestingHydrated and Temperature Controlled Testing

Bone Tissue Engineering & MechanicsMechanotransductionOrganoid and Tissue Mimetic SystemsStem Cell Mechanobiology

2026

A Mechanically Stimulated Co-culture in 3-Dimensional Composite Scaffolds Promotes Osteogenic and Anti-osteoclastogenic Activity and M2 Macrophage Polarization

Kontogianni G, Loukelis K, et al.

Biomaterials Research

MechanoCulture TX

Compression TestingHydrated and Temperature Controlled Testing

3D Bioprinting & Bioink Materials TestingBone Tissue Engineering & MechanicsMechanotransductionScaffold Mechanical TestingStem Cell Mechanobiology

2025

Injectable Piezoelectric Hydrogel for Vital Pulp Therapy

Solanki V, Montoya C, et al.

Journal of Functional Biomaterials

MechanoCulture TX

Compression TestingHydrated and Temperature Controlled Testing

Dental & Oral Tissue BiomechanicsHydrogel Mechanical TestingInjectable & Regenerative BiomaterialsMechanotransductionStem Cell MechanobiologyStimuli Responsive Hydrogels Characterization

2025