Mineralization of Bone Extracellular Matrix-like Scaffolds Fabricated as Silk Sericin-Functionalized Dense Collagen–Fibrin Hybrid Hydrogels

Griffanti G, McKee MD, et al.

Pharmaceutics

McGill University

RESEARCH SUMMARY

This study developed silk sericin-functionalized collagen–fibrin hydrogels mimicking bone ECM. Sericin enhanced calcium binding and hydroxyapatite formation, increasing stiffness and promoting osteogenic differentiation of MC3T3-E1 cells.

The CellScale UniVert measured tensile strength and modulus of collagen–fibrin–sericin hydrogels, revealing that sericin incorporation significantly increased stiffness and strength, validating functionalization-induced mechanical enhancement.

AUTHORS

Gabriele Griffanti; Marc D. McKee; Showan N. Nazhat.

PUBLICATION DETAILS

JOURNAL

Pharmaceutics

YEAR

2023

INSTITUTIONS

McGill University

COUNTRIES

Canada

INSTRUMENT USED

UniVert

TESTING METHODS

Tensile Testing

RESEARCH APPLICATIONS

Bone Tissue Engineering & MechanicsCell Laden HydrogelsECM & Decellularized Matrix MechanicsHydrogel Mechanical TestingInjectable & Regenerative BiomaterialsStem Cell Mechanobiology

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