Mechanical signaling regulates vascular smooth muscle cell adaptation in aging

Mohajeri A, Shin SY, et al.

Frontiers in Physiology

Texas A&M University

RESEARCH SUMMARY

Mechanical stimulation of vascular smooth muscle cells from aged rats restored contractility via integrin β1 and actin remodeling, mimicking the beneficial effects of exercise on aging arteries.

Used the MechanoCulture TR to apply 16 kPa hydrostatic pressure to VSM cells for 30 min, reproducing physiological pressure to study aging-related mechanoadaptation.

AUTHORS

Mohajeri A, Shin SY, Padgham S, Boland DJ, Pittman Ratterree D, Blizman J, Han G, Woodman CR, Trache A..

PUBLICATION DETAILS

JOURNAL

Frontiers in Physiology

YEAR

2025

INSTITUTIONS

Texas A&M University

COUNTRIES

United States

INSTRUMENT USED

MechanoCulture TR

TESTING METHODS

Hydrated and Temperature Controlled TestingHydrostatic Pressure Testing

RESEARCH APPLICATIONS

Fibrosis & Tissue RemodelingMechanotransductionVascular Tissue Engineering & Mechanics

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