Graded electrospun scaffold from aligned fibers to honeycomb micropatterns: Application to bone–tendon tissue engineering

Rivoallan N, Baudequin T, et al.

Biomaterials Advances

Université de Technologie de Compiègne, Leibniz Universitat Hannover, CNRS, Sorbonne Université, INSERM

RESEARCH SUMMARY

Developed a graded electrospun scaffold with aligned fibers to honeycomb patterns mimicking the bone–tendon interface. Dynamic loading (3% strain, 12 cycles) enhanced osteogenic activity and cell alignment, confirming mechanical stimulation supports enthesis regeneration.

Used the MechanoCulture T6 bioreactor to apply cyclic tensile strain (3%) for 7 days on multi-well scaffolds, enabling dynamic culture under sterile, incubator-controlled conditions and supporting real-time imaging and assays.

AUTHORS

Rivoallan N, Baudequin T, Mueller M, Nicolas R, Leal Marin S, Vigneron P, Jellali R, Dermigny Q, Le Goff A, Duprez D, Glasmacher B, Legallais C..

PUBLICATION DETAILS

JOURNAL

Biomaterials Advances

YEAR

2025

INSTITUTIONS

Université de Technologie de Compiègne, Leibniz Universitat Hannover, CNRS, Sorbonne Université, INSERM

COUNTRIES

France, Germany

INSTRUMENT USED

MechanoCulture T6

TESTING METHODS

Fatigue TestingHydrated and Temperature Controlled TestingTensile Testing

RESEARCH APPLICATIONS

Bone Tissue Engineering & MechanicsMechanotransductionMusculoskeletal Tissue Engineering & MechanicsScaffold Mechanical TestingTendon Tissue Engineering & Ligament Mechanics

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