Evaluating the Angiogenic and Mechanical Properties of Hydrogels and Physical Constructs Derived from Spinal Cord Meninges Extracellular Matrix

This study developed ECM-derived hydrogel (MeninGEL) and cryogel (MeninRIX) constructs from decellularized bovine spinal cord meninges to evaluate their suitability for regenerative medicine applications. Comprehensive biochemical analysis confirmed effective decellularization while preserving key extracellular matrix components. Mechanical testing demonstrated that MeninGEL closely matched brain-like mechanical properties, whereas MeninRIX aligned with spinal cord stiffness ranges. In ovo CAM assays revealed strong angiogenic responses and scaffold integration, supporting the use of meninges-derived ECM constructs as mechanically and biologically appropriate biomaterials for soft tissue regeneration.