Dual-Component Nanofiber Scaffolds of Silica and Collagen for Enhanced Mechanical Integrity and Osteogenic Bioactivity

Develops hybrid electrospun nanofiber (SifCo) scaffolds by dual-nozzle spinning silica sol with fibrillated collagen. Hybridization markedly improves mechanics and bioactivity: Young’s modulus increases from 13±1 MPa (silica) to 69±25 MPa (SifCo); tensile strength rises from 0.3±0.1 MPa (silica) to 2.0±0.8 MPa (SifCo). SifCo exhibits slower degradation than collagen NFs (~15% vs ~83% mass loss at 14 days) and supports hBMSC proliferation and mineralization (Alizarin Red). Results indicate balanced stability and osteogenic performance.