PEER-REVIEWED PUBLICATION

2025

Dual-Component Nanofiber Scaffolds of Silica and Collagen for Enhanced Mechanical Integrity and Osteogenic Bioactivity

Jalali S, Jamadi Khiabani M, et al.

Materials & Design

Technische Universität Dresden, Uppsala University, Institut für Bioprozess- und Analysentechnik e.V., Friedrich Schiller University Jena

Germany, Sweden

RESEARCH SUMMARY

Develops hybrid electrospun nanofiber (SifCo) scaffolds by dual-nozzle spinning silica sol with fibrillated collagen. Hybridization markedly improves mechanics and bioactivity: Young’s modulus increases from 13±1 MPa (silica) to 69±25 MPa (SifCo); tensile strength rises from 0.3±0.1 MPa (silica) to 2.0±0.8 MPa (SifCo). SifCo exhibits slower degradation than collagen NFs (~15% vs ~83% mass loss at 14 days) and supports hBMSC proliferation and mineralization (Alizarin Red). Results indicate balanced stability and osteogenic performance.

Uniaxial tensile testing was performed on a CellScale UniVert with a 10 N load cell. Dumbbell specimens (~10–7 mm width, 30 mm length) were tested at 23±2 °C and 42±5% RH using pneumatic grips. Stretch magnitude was 20%; Young’s modulus and yield tensile stress were computed from stress–strain data for silica, collagen, and SifCo mats.

AUTHORS

Jalali S; Jamadi Khiabani M; Kruppke I; Lee PS; Heinemann C; Wiesmann H-P; Varghese OP; Kruppke B.

PUBLICATION DETAILS

JOURNAL

Materials & Design

YEAR

2025

INSTITUTIONS

Technische Universität Dresden, Uppsala University, Institut für Bioprozess- und Analysentechnik e.V., Friedrich Schiller University Jena

COUNTRIES

Germany, Sweden

INSTRUMENT USED

UniVert

TESTING METHODS

Tensile Testing

RESEARCH APPLICATIONS

Bone Tissue Engineering & MechanicsECM & Decellularized Matrix MechanicsInjectable & Regenerative BiomaterialsMembranes and Thin Films MechanicsMusculoskeletal Tissue Engineering & MechanicsPolymers and Elastomers Testing

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