Biodegradable Synthetic Graft with Sustained Hydrogen Sulfide Release Promotes Endothelial Cell Growth

The study designs an H₂S‑releasing, resorbable synthetic vascular graft by electrospinning and photocuring functional polyesters that bear free thiols. A methacrylated H₂S donor is conjugated via thiol‑ene click chemistry to enable sustained H₂S release (~12 days) while maintaining elasticity, appropriate degradation, and porosity. At proof‑of‑concept, the low‑rate H₂S‑releasing graft significantly enhanced endothelial cell growth in vitro, paving the way for in vivo evaluation.