PEER-REVIEWED PUBLICATION

2025

Are Soft Silicone Hydrogel Contact Lenses More Compliant in a Warm, Hydrated Environment?

A tensile test divider icon

Towler J, Lin WP, et al.

Processes

University of Liverpool, Mackay Medical University, Brighten Optix Corporation, University of Cambridge, Pacific University

RESEARCH SUMMARY
This study examined how temperature and hydration affect the mechanical and optical properties of silicone hydrogel contact lenses. Two materials, Definitive 74 and Unisil, were evaluated under room (24 °C) and physiological (35 °C) conditions. Both materials softened at higher temperature, with Definitive 74 showing a larger modulus drop (0.40 → 0.32 MPa) than Unisil (0.73 → 0.70 MPa). Finite element modeling showed that increased compliance at 35 °C significantly influenced refractive power, especially when the lens base curve differed from corneal radius by >5 %. The work demonstrates that soft lenses are more compliant in warm, hydrated conditions, emphasizing the importance of physiologically relevant testing for accurate optical and comfort predictions.
CellScale hexagons, without text

CELLSCALE INSTRUMENT USED

UniVert

Uniaxial tensile and compression tests were performed using a CellScale UniVert mechanical tester (1 N and 50 N load cells, 0.1 mN/0.1 N precision) in a temperature-controlled PBS bath at 24 °C and 35 °C. The UniVert provided precise low-force measurements critical for soft lens characterization. The instrument enabled stress–strain curve generation, from which Ogden hyperelastic parameters were derived and validated via finite-element analysis on an eye model.
AUTHORS

Towler J, Lin W-P, Wu L-Y, Abass R, Wu R, Fathy A, Alanazi R, Davies J, Abass A.

PUBLICATION DETAILS
JOURNAL

Processes

YEAR

2025

INSTITUTIONS

University of Liverpool, Mackay Medical University, Brighten Optix Corporation, University of Cambridge, Pacific University

COUNTRIES

Taiwan, United Kingdom, United States

INSTRUMENT USED

UniVert

TESTING METHODS

Compression TestingHydrated and Temperature Controlled TestingTensile Testing

RESEARCH APPLICATIONS

Hydrogel Mechanical TestingMembranes and Thin Films MechanicsOphthalmic Biomechanics & Corneal Tissue EngineeringPolymers and Elastomers Testing

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Product of Interest:
CellScale hexagon shapes