Open‑porous Magnesium‑Based Scaffolds Withstand In Vitro Corrosion Under Cyclic Loading: A Mechanistic Study

This study investigates how cyclic mechanical loading influences the corrosion behavior, structural evolution, and mechanical integrity of open-porous fluoride-coated magnesium scaffolds designed for bone regeneration. By combining dynamic immersion in simulated physiological media with cyclic compressive loading, the authors demonstrate that although cyclic loading accelerates corrosion, the scaffold maintains mechanical integrity through structural densification driven by corrosion product accumulation. The results show that these magnesium scaffolds retain load-bearing capacity under physiologically relevant cyclic compression, supporting their potential use as temporary biodegradable bone substitutes during early healing phases.