Hydroxyapatite-Filled Osteoinductive and Piezoelectric Nanofibers for Bone Tissue Engineering

This study developed electrospun polymer scaffolds incorporating hydroxyapatite (HA) particles to create osteoinductive and piezoelectric membranes for bone regeneration applications. The addition of HA was shown to significantly influence scaffold morphology, fiber alignment, tensile mechanical properties, and piezoelectric response. Tensile testing demonstrated that increasing HA content enhanced elastic modulus and tensile strength while maintaining flexibility suitable for handling and implantation. In vitro studies with osteogenic cells showed improved cell adhesion, proliferation, and differentiation on HA-containing scaffolds, supporting the use of mechanically robust, electroactive fibrous membranes as functional bone-regenerative materials.