PEER-REVIEWED PUBLICATION

2025

Mechanical stimulation in 2D: A potent accelerator of matrix mineralization in ATDC5 chondrogenic cells

Quexada-Rodriguez Q, Messelmani T, et al.

Journal of Orthopaedics

Université de Technologie de Compiègne, Universidad Nacional de Colombia, CNRS, GNUM

RESEARCH SUMMARY

Cyclic tensile strain (12%, 0.05 Hz) applied to ATDC5 cells accelerated matrix mineralization and cell hypertrophy, demonstrating mechanical stimulation promotes osteogenic differentiation in 2D culture.

The MechanoCulture T6 applied 12% cyclic tensile strain at 0.05 Hz for 1 h/day over 5 days, enabling controlled uniaxial loading for chondrocyte mechanobiology experiments.

AUTHORS

Quexada-Rodríguez D, Messelmani T, Jellali R, Le Goff A, Ho Ba Tho M-C, Garzon-Alvarado D, Trabelsi O..

PUBLICATION DETAILS

JOURNAL

Journal of Orthopaedics

YEAR

2025

INSTITUTIONS

Université de Technologie de Compiègne, Universidad Nacional de Colombia, CNRS, GNUM

COUNTRIES

Colombia, France

INSTRUMENT USED

MechanoCulture T6

TESTING METHODS

Fatigue TestingHydrated and Temperature Controlled TestingTensile Testing

RESEARCH APPLICATIONS

Bone Tissue Engineering & MechanicsCartilage and Meniscus MechanicsMechanotransductionStem Cell Mechanobiology

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