PEER-REVIEWED PUBLICATION

2023

Mechanical and morphological characterisation of porcine urethras for the assessment of paediatric urinary catheter safety

Cunnane EM, Cunnane CV, et al.

Journal of the Mechanical Behavior of Biomedical Materials

University of Limerick, Beaumont Hospital, Tissue Engineering Research Group, Royal College of Surgeons in Ireland, Class Medical Ltd., University Hospital Limerick

RESEARCH SUMMARY
This study investigated the mechanical and morphological behavior of porcine urethral tissue to develop a preclinical model for assessing the safety of paediatric urinary catheters. Juvenile porcine urethras were analyzed via pressure–diameter and uniaxial tensile testing. Results showed that pressure-limited inflation at 150 kPa prevented rupture, while uncontrolled inflation caused tearing. Morphology analysis confirmed that 8–12 week pig tissue mimics pediatric urethral geometry. These findings provide a reproducible ex vivo model for evaluating pediatric catheter design and pressure safety thresholds.

CELLSCALE INSTRUMENT USED

BioTester

The CellScale BioTester 5000 was used as part of a pressure–diameter testing setup to record real-time images of urethral deformation during inflation. The BioTester’s imaging and transducer system measured compliance and tangent modulus, validating tissue stiffening and identifying safe pressure thresholds for catheter testing.
AUTHORS

Eoghan M. Cunnane; Connor V. Cunnane; Joanna M. Allardyce; Stefanie M. Croghan; Michael T. Walsh; Niall F. Davis; Hugh D. Flood; John J.E. Mulvihill.

PUBLICATION DETAILS
JOURNAL

Journal of the Mechanical Behavior of Biomedical Materials

YEAR

2023

INSTITUTIONS

University of Limerick, Beaumont Hospital, Tissue Engineering Research Group, Royal College of Surgeons in Ireland, Class Medical Ltd., University Hospital Limerick

COUNTRIES

Ireland

INSTRUMENT USED

BioTester

TESTING METHODS

Hydrated and Temperature Controlled TestingPressure TestingViscoelastic & Time-Dependent Testing

RESEARCH APPLICATIONS

ECM & Decellularized Matrix MechanicsFibrosis & Tissue RemodelingGastrointestinal and Urinary Tract Biomechanics

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