Investigation of the Frictional Characteristics of a Manufactured Tendon Lubricant in Canine Peroneus Longus (PL) Tendons In Vitro

This study evaluated the biomechanical performance of a Manufactured Tendon Lubricant (MTL) developed under good manufacturing practice standards to reduce tendon adhesion following reconstructive hand surgery. Using an in vitro canine peroneus longus tendon model, the authors compared frictional behavior and elastic modulus of tendons treated with MTL versus saline controls. MTL-treated tendons exhibited significantly reduced friction and gliding resistance, along with increased elastic modulus, indicating effective surface fixation and crosslinking. These results demonstrate that MTL provides durable lubrication and mechanical reinforcement of tendon surfaces, supporting its potential suitability for translation to human clinical applications.