A composite hydrogel membrane with shape and water retention for corneal tissue engineering

Jiang L, Dong X, et al.

Heliyon

Tianjin Medical University, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital

RESEARCH SUMMARY

This work developed a composite sodium alginate–gelatin hydrogel that mimics corneal tissue properties. The gelatin-coated AlgF–Gel hydrogels showed improved transparency, water retention, and fibroblast compatibility, making them suitable corneal scaffolds.

The CellScale BioTester 5000 was used for tensile testing of hydrogel membranes at 37 °C. It quantified modulus and elongation, confirming gelatin coating improved uniformity and mechanical stability for corneal tissue applications.

AUTHORS

Li Jiang; Xiaoli Dong; Luxia Chen; Ruifang Han; Pen Hao; Liming Wang; Juan Gao; Xi Chen; Xuan Li.

PUBLICATION DETAILS

JOURNAL

Heliyon

YEAR

2023

INSTITUTIONS

Tianjin Medical University, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital

COUNTRIES

China

INSTRUMENT USED

BioTester

TESTING METHODS

Hydrated and Temperature Controlled TestingTensile Testing

RESEARCH APPLICATIONS

Cell Laden HydrogelsHydrogel Mechanical TestingMembranes and Thin Films MechanicsOphthalmic Biomechanics & Corneal Tissue Engineering

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