CellScale BlogWelcome to our blog page! This is split into different series of stories. Check out the In the Lab series where we catch up with researchers using CellScale systems. Caleb's Corner is where our president pens his insights on the industry. Finally the Product Launch series introduces the latest in CellScale R&D. Enjoy browsing!
Dr. Elena Bulanova and her team at the Laboratory for Biotechnological Research 3D Bioprinting Solutions in Russia present their article on fabrication and analysis of tissue spheroids. Their design protocol applies to any cell line and aims to meet high quality standards such as consistent geometry, defined mechanical properties and viability.
CellScale User Publication Highlight: Promoting Maturation of hiPSC-derived Cardiomyocytes with Re-entrant Waves
Dr. Li Liu and her team at the Osaka University Graduate School of Medicine present their breakthrough research to mature hiPSC-derived cardiomyocytes in a self-organized tissue ring. By mimicking the physiology of adult cardiomyocytes, the team’s findings present a viable solution to drug screening and regenerative therapy applications.
Dr. Ali Tamayol and his team from the University of Nebraska-Lincoln developed a wearable device that can deliver agents to critical layers of the wound bed in a minimally invasive fashion. Read more about their solution to treat chronic wounds suffered by diabetic patients.
Dr. Jon Pokorski and his team from the University of California at San Diego presents a solution to high-cost, bulky and high-material-consuming melt-processing system for academic laboratories. In his study, he demonstrates the dispersion of particles in melt processed polymers produced by their invention.
CellScale User Publication Highlight: The Effect of Cyclic Stretch and Shear Stretch on Inflammation and Tissue Formation
Dr. Carlijn V.C. Bouten and her team at the Eindhoven University of Technology explored into the underlying mechanisms of premature graft failure by creating a human in vitro model of material-driven vascular regeneration. Read on to discover how cyclic stretch and shear stretch respectively affects inflammation and tissue formation.
CellScale User Publication Highlight: Hyperelastic Characterization of Mesh for Abdominal Hernia Repair
Dr. Georgina Carbajal de la Torre and her team from Universidad Michoacana de San Nicolas de Hidalgo in Mexico shares with us her fascinating research into various synthetic mesh for abdominal wall hernia repair. By understanding the mechanical properties of these materials, surgical treatments of abdominal hernia can vastly improve thus reducing the hernia recurrence rate for patients.
Ludovica Cacopardo from the University of Pisa under Associate Professor Arti Ahluwalia publishes this article on a new testing method for viscoelasticity through stress-rate measurements and load-control testing. Learn how the MechanoCulture TR played a major role in their discovery.
Here is the first customer publication highlight featuring a commercial (non-academic) entity and their research with our equipment! Dr. Desmond Adler and his team from Avedro (now a Glaukos company) investigated on the optimization of oxygen dynamics, UV-A delivery, and drug formulation for Accelerated Epi-On Corneal Crosslinking.
University of Arizona’s Dr. Jeong-Yeol Yoon and his Ph.D. student Kattika Kaarj presents this journal paper on Organ-on-a-chip devices and the mechanical stimuli they can create on human cells and tissues. This excellent summary focuses on the technical details of device design and equipment used, categorizing them under 5 types of mechanical stimuli.
CellScale User Publication Highlight: Effects of Different Constitutive Laws on Fluid-Structure Interaction (FSI) Simulation of the Mitral Valve
Dr. Xiaoyu Luo from the University of Glasgow in collaboration with 3 top scientific universities in China has presented a highly detailed study on the dynamic behavior of mitral valve leaflets and chordae tendineae under physiological conditions.
CellScale User Publication Highlight: Nb2O5 and HA Particle Loaded Electrospun PCL/GL Membranes for Bone Tissue Engineering
Dr. Kathryn Grandfield and her team from McMaster University in collaboration with Federal University of Pelotas designed and fabricated membranes with the ideal bone quality and bioactivity favoured in bone repair applications. Learn more about their methods and test results.
CellScale User Publication Highlight: Surface Representation and Bio-mechanical Analysis of the Urinary Bladder
Dr. Alejandro Garcia-Gonzalez from Tecnologico de Monterrey in collaboration with the University of Texas at Dallas presents this paper that characterizes the urinary bladder in research to benefit the treatment of stress urinary incontinence.
CellScale User Publication Highlight: Regional-Dependent Biaxial Behavior of Young and Aged Mouse Skin
Dr. Manuel Rausch and his team at the University of Texas at Austin published this comprehensive study on the detailed histomechanical characterization, residual strain
analysis, and constitutive mode of murine skin.
CellScale presents the latest innovation in microphysiological systems.
Dr. Diane Gregory and Maxine Harvey-Burgess from Wilfrid Laurier University published this article in Spine Biomechanics journal that studied the effect of axial torsion on the mechanical properties of the annulus fibrosus inter- and intralamellar matrices.
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CellScale User Publication Highlight: Compressive Mechanical Properties of Rat and Pig Optic Nerve Head
Dr. Ross Ethier and his team from Georgia Institute of Technology furthered the research on Glaucoma through biomechanical studies on the optic nerve head tissue of a rat and pig.
CellScale User Publication Highlight: Effect of Halloysite Addition on the Material Properties of Chitosan-Halloysite Hydrogel Composites
Chitosan is an exceptional candidate for implant coatings, wound dressing, and drug delivery applications. However, it has poor mechanical properties on its own and often needs to be reinforced with other polymers, carbon nanotubes or clay nanoparticles. Dr. David Mills and Yangyang Luo from Louisiana Tech University explores the addition of Halloysite in Chitosan, studying the material properties as well as its drug delivery capabilities.