MCFX

High throughput uniaxial stimulation of cell cultures with real-time imaging.

The MCFX uses a single-use flexible silicone well plate to culture cells in much the same environment as a traditional polystyrene well plate. After allowing the cells to develop adhesion to the well bottom, the MCFX can execute a user-specified stretch protocol to the well plate, causing the cells to deform. The well bottoms have similar optical properties to a glass coverslip, permitting high-magnification imaging of the cultured cells. The well plates can be sterilized and the system is suitable for long-term cell culture in a laboratory incubator.

Key Features

  • Uniaxial stretch of 16 culture wells in a single-use silicone well plate
  • 0.25mm thick membranes for high-magnification imaging using an inverted microscope
  • PC-independent operation
  • User-friendly interface software for specifying simple, cyclic, and intermittent stimulation protocols for download to the device controller
MCFX Image

Adhered Cell Monolayer Culture

Single-use silicone well plate.  Cell culture wells are 8mm X 8mm with a 0.25mm thick transparent bottom membrane. The 16 cell culture surfaces are shown in red.

3D Gel Scaffold Culture

The 3D gel culture plate has 18 micro-protrusions on the bottom membrane of each well to secure the gel in place during the stretching protocol.

What Our Customers Are Saying

Don’t just take it from us, let our customers do the talking!

We are using CellScale equipment for the last two years to assess the influence of mechanical stimulation on permanently differentiated and stem cells' fate. The interface is user-friendly, the customer support service is very helpful, the equipment is easy to use and inexpensive, yet precise and robust.

Prof. Dimitrios Zeugolis

National University of Ireland Galway

The CellScale MechanoCulture has been a very versatile bioreactor platform for us. It's size and the ability to pre-program the bioreactor conditions results in a cost-effective solution to our bioreactor needs. In addition, the software is intuitive and easy to use. CellScale has been easy to work with and has quickly addressed any issues we have come across.

Prof. Brian Amsden

Queens University

Videos

TECHNICAL INFO

Dimensions 19 X 9 X 10cm
Weight 1kg
Stimulation mode Uniaxial tension
Configuration Cell monolayer, 3D gel
Culture area 16 wells, 8mm X 8mm
Maximum strain 20%
Maximum Velocity 10mm/s
Maximum Cycle Frequency 5Hz
Loading capacity 30N
Media volume/well 0.5mL

 

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